M. tuberculosis intramembrane protease Rip1 controls transcription through three anti-sigma factor substrates
نویسندگان
چکیده
منابع مشابه
The Rip1 protease of Mycobacterium tuberculosis controls the SigD regulon.
Regulated intramembrane proteolysis of membrane-embedded substrates by site-2 proteases (S2Ps) is a widespread mechanism of transmembrane signal transduction in bacteria and bacterial pathogens. We previously demonstrated that the Mycobacterium tuberculosis S2P Rip1 is required for full virulence in the mouse model of infection. Rip1 controls transcription in part through proteolysis of three t...
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Site-2 proteases (S2Ps) are intramembrane metalloproteases that cleave transmembrane substrates in all domains of life. Many S2Ps, including human S2P and Mycobacterium tuberculosis Rip1, have multiple substrates in vivo, which are often transcriptional regulators. However, S2Ps will also cleave transmembrane sequences of nonsubstrate proteins, suggesting additional specificity determinants. Ma...
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Receptor Ser/Thr protein kinases are candidates for sensors that govern developmental changes and disease processes of Mycobacterium tuberculosis (Mtb), but the functions of these kinases are not established. Here, we show that Mtb protein kinase (Pkn) D overexpression alters transcription of numerous bacterial genes, including Rv0516c, a putative anti-anti-sigma factor, and genes regulated by ...
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Yanet Romero, Soledad Moreno, Josefina Guzmán, Guadalupe Espín and Daniel 4 Segura # 5 6 Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad 7 Nacional Autónoma de México, Cuernavaca, Morelos, México. 8 9 # Corresponding author. 10 Email: [email protected] 11 12 13 14 15 Mailing address: 16 Departamento de Microbiología Molecular, Instituto de Biotecnología UNAM 17...
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Mycobacterium tuberculosis, an obligate mammalian pathogen, adapts to its host during the course of infection via the regulation of gene expression. Of the regulators of transcription that play a role in this response, several alternative sigma factors of M. tuberculosis have been shown to control gene expression in response to stresses, and some of these are required for virulence or persisten...
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ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 2010
ISSN: 0950-382X
DOI: 10.1111/j.1365-2958.2010.07232.x